Tilly had small roles in TV shows and movies beginning in 1983. She had a recurring guest role on Hill Street Blues as Gina Srignoli, a mobster’s widow who becomes romantically involved with detective Henry Goldblume. Jennifer Tilly also appeared as Garry’s girlfriend on It’s Garry Shandling’s Show, which aired on Showtime in the mid 1980’s.
Tilly’s breakthrough film role was as a singing waitress in The Fabulous Baker Boys (1989) in a part that was specially written for her by Steve Kloves. That same year, she played a small part in the cult classic horse racing movie, Let it Ride with Richard Dreyfuss and Teri Garr, that Tilly later said “should have done better.”
She was nominated for an Academy Award for Best Supporting Actress for her role as a hopelessly bad actress in Woody Allen’s Bullets Over Broadway (1994). In 1994, she also had a small role in the The Getaway with Alec Baldwin and Kim Basinger. Tilly was ranked #23 in Celebrity Sleuth “25 Sexiest Women of 1995.”
Tilly appeared in Bound, which revolves around a lesbian relationship her character has with Gina Gershon. She played Samantha Cole in the 1997 Jim Carrey hit Liar Liar. In 2000, Tilly appeared in the film Dancing at the Blue Iguana in which she played a stripper and part-time dominatrix.
Tilly gained some additional popularity in recent years for providing voice-over work as killer doll Tiffany for the Child’s Play series of movies. In the most recent installment, Seed of Chucky, she plays a dual role, not only providing the voice for Tiffany but also playing an exaggerated version of herself.
Tilly is a semi-regular cast member on Family Guy, voicing the Griffin family’s permanently pregnant neighbor, Bonnie Swanson. She has also done vocal work for the films Monsters, Inc., Stuart Little, and Home on the Range, as well as the children’s series Hey Arnold, In Disney’s The Haunted Mansion, she does the voice-over for Madame Leota and works from the neck up. She has been active in the theatre, winning a Theater World Award for her performance in the off-Broadway play One Shoe Off.
Tilly has also had a starring role in the US television comedy Out of Practice starring Henry Winkler and Stockard Channing. The series was canceled shortly after.
